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The recent withdrawal of artefenomel from clinical development leaves no endoperoxide-class agents in the antimalarial pipeline. …

Iron is an essential element for life owing to its ability to participate in a diverse array of oxidation–reduction reactions. However, …

Chemoselective modification of specific residues within a given protein poses a significant challenge, as the microenvironment of amino …

The creation of versatile platforms for developing dual-channel near-infrared fluorescent (NIRF) and photoacoustic (PA) probes, …

Protein acetylation is one of the extensively studied post-translational modifications (PTMs) due to its significant roles across a …

In this study, we investigated how BPNS inhibits the invasion and migration of GBM cells both in vitro and in vivo by suppressing the WNT/β-catenin signaling pathway. Our results demonstrate that BPNS directly binds to CSNK2A2, reducing its kinase activity, which, in turn, increases GSK-3β activity. Consequently, GSK-3β promotes β-catenin degradation, leading to the inhibition of the WNT/β-catenin signaling pathway and downregulation of key downstream genes like Axin2, CD44, and Notch1. The reduced Notch1 levels inhibit the NOTCH pathway, further downregulating Jag1, Hes1, and Akt1. Overall, this study uncovers BPNS’s inhibitory effect on invasion and migration in GBM cells and reveals the underlying molecular mechanism, offering potential avenues for future GBM treatments.

we report that the direct treatment of BPNs can improve the survival rate of NPCs and enhance the neural differentiation of NPCs. These biological effects of BPNs on NPCs are comprehensively demonstrated and can be primarily attribute to the up-regulation of Nrf2 in NPCs induced by BPNs. In SCI mice, BPNs are demonstrated with enhanced neuroprotection to NPCs. BPNs-treated NPCs effectively reduce glial scar formation and promote axon regeneration, demonstrating a better nerve repair effect. Our proposed biodegradable BPNs-based stem cell therapy provides more informative support for improving the efficacy of stem cell transplantation for nerve damage diseases

Lysine lactylation (Kla) is a novel histone post-translational modification discovered in late 2019. Later, HDAC1-3, were identified as …

Super-resolution imaging provides a powerful approach to image dynamic biomolecule events at nanoscale resolution. An ingenious method …

Dynamically controlling the post-translational modification of the ε-amino groups of lysine residues is critical for regulating many …