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Black phosphorus nanosheets enhance differentiation of neural progenitor cells for improved treatment in spinal cord injury
we report that the direct treatment of BPNs can improve the survival rate of NPCs and enhance the neural differentiation of NPCs. These biological effects of BPNs on NPCs are comprehensively demonstrated and can be primarily attribute to the up-regulation of Nrf2 in NPCs induced by BPNs. In SCI mice, BPNs are demonstrated with enhanced neuroprotection to NPCs. BPNs-treated NPCs effectively reduce glial scar formation and promote axon regeneration, demonstrating a better nerve repair effect. Our proposed biodegradable BPNs-based stem cell therapy provides more informative support for improving the efficacy of stem cell transplantation for nerve damage diseases
Fumei He, Ke Cheng, Junyang Qi, Fangjie He, Chengjun Chu, Yue Xiong, Jingxin Zhao, JiaQi Ding, FanShu Kong, ZiMeng Cao, Gan Liu, Wenbin Deng
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Black phosphorus nanosheets enhance differentiation of neural progenitor cells for improved treatment in spinal cord injury
Identification of SIRT3 as an eraser of H4K16la
Lysine lactylation (Kla) is a novel histone post-translational modification discovered in late 2019. Later, HDAC1-3, were identified as …
Zhuming Fan, Zhiyang Liu, Nan Zhang, Wenyu Wei, Ke Cheng, Hongyan Sun, Quan Hao
PDF Cite DOI CellPress PubMed
Identification of SIRT3 as an eraser of H4K16la
De novo designed self-assembling rhodamine probe for real-time, long-term and quantitative live-cell nanoscopy
Super-resolution imaging provides a powerful approach to image dynamic biomolecule events at nanoscale resolution. An ingenious method …
Jie Zhang, Heng Shi, Chen Huang, Le Mei, Qiang Guo, Ke Cheng, Pingzhou Wu, Dan Su, Qingxin Chen, Shenglong Gan, Cecilia Ka Wing Chan, Jiahai Shi, Jian Lin Chen, Chung Hang Jonathan Choi, Shao Q. Yao, Xian-Kai Chen, Ben Zhong Tang, Jufang He, Hongyan Sun
PDF Cite DOI ACS Publications PubMed
De novo designed self-assembling rhodamine probe for real-time, long-term and quantitative live-cell nanoscopy
Universal strategy to develop fluorogenic probes for kysine deacylase/demethylase activity and application in discriminating demethylation states
Dynamically controlling the post-translational modification of the ε-amino groups of lysine residues is critical for regulating many …
Wenyu Wei, Jie Zhang, Zhiqiang Xu, Zhiyang Liu, Chen Huang, Ke Cheng, Lingkuan Meng, Yudai Matsuda, Quan Hao, Huatang Zhang, Hongyan Sun
PDF Cite DOI ACS Publications
Universal strategy to develop fluorogenic probes for kysine deacylase/demethylase activity and application in discriminating demethylation states
Self-assembled nano-photosensitizer for targeted, activatable, and biosafe cancer phototheranostics
We have developed a GSH-triggered, activatable, and cancer-targeting probe, MBP, based on our rational design of a small NIRF photosensitizer, methylene blue. This multifunctional probe can self-assemble and present as nano-photosensitizer, MBNPs. Hence, an “all-in-one” cancer phototheranostic strategy with multiple cancer-targeting abilities and upgraded PDT mode has been proposed and established.
Ke Cheng, Junyang Qi, Jie Zhang, Huangxu Li, Xiaojie Ren, Wenyu Wei, Lingkuan Meng, Jing Li, Qianqian Li, Huatang Zhang, Wenbin Deng, Hongyan Sun, Lin Mei
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Self-assembled nano-photosensitizer for targeted, activatable, and biosafe cancer phototheranostics
Developing isoxazole as a native photo-cross-linker for photoaffinity labeling and chemoproteomics
Isoxazole is an essential pharmacophore in drug discovery. In this study, we investigated the photochemistry of isoxazole with biomolecules and developed it as a natively embedded photo-cross-linker for chemoproteomics and drug discovery. With this strategy, two isoxazole-containing drugs were successfully applied to chemoproteomic platforms to uncover their cellular targets and interactions.
Ke Cheng, Junyang Qi, Xiaojie Ren, Jie Zhang, Huangxu Li, Hanyue Xiao, Rui Wang, Zhiyang Liu, Lingkuan Meng, Nan Ma, Hongyan Sun
PDF Cite DOI Wiley Online Library PubMed
Developing isoxazole as a native photo-cross-linker for photoaffinity labeling and chemoproteomics
Mini-review: Recent advances in post-translational modification site prediction based on deep learning
Post-translational modifications (PTMs) are closely linked to numerous diseases, playing a significant role in regulating protein …
Lingkuan Meng, Wai-Sum Chan, Lei Huang, Linjing Liu, Xingjian Chen, Weitong Zhang, Fuzhou Wang, Ke Cheng, Hongyan Sun, Ka-Chun Wong
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Mini-review: Recent advances in post-translational modification site prediction based on deep learning
Robust artificial interphases constructed by a versatile protein-based binder for high-voltage Na-ion battery cathodes
The multiple issues of unstable electrode/electrolyte interphases, sluggish reaction kinetics, and transition-metal (TM) dissolution …
Huangxu Li, Chaohong Guan, Jie Zhang, Ke Cheng, Qingxin Chen, Liang He, Xiaochen Ge, Yanqing Lai, Hongyan Sun, Zhian Zhang
PDF Cite DOI Wiley Online Library PubMed
Robust artificial interphases constructed by a versatile protein-based binder for high-voltage Na-ion battery cathodes
Organic/inorganic anions coupling enabled reversible high-valent redox in vanadium-based polyanionic compound
Recently, there has been a drive to design and develop mixed polyanion compounds for positive electrode applications in sodium-ion …
Huangxu Li, Chaohong Guan, Ming Xu, Jun Guo, Kuo Yuan, Ke Cheng, Yangyang Xie, Liuyun Zhang, Jingqiang Zheng, Yanqing Lai, Zhian Zhang
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Organic/inorganic anions coupling enabled reversible high-valent redox in vanadium-based polyanionic compound
Pseudocapacitance enhanced by N-defects in Na3MnTi(PO4)3/N-doped carbon composite for symmetric full sodium-ion batteries
The concept of symmetric full battery attracts increasing attention in recent years. The symmetric battery consists of two identical …
H. Li, W. Zhang, Z. Han, K. Sun, C. Gao, Ke Cheng, Z. Liu, Q. Chen, J. Zhang, Y. Lai, Z. Zhang, H. Sun
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Pseudocapacitance enhanced by N-defects in Na3MnTi(PO4)3/N-doped carbon composite for symmetric full sodium-ion batteries