Ke Cheng

Ke Cheng

Postdoctoral Researcher

University of California, San Francisco (UCSF)

Biography

My research focuses on using new chemical approaches to advance drug discovery and therapeutic options. I have developed tetrazole and isoxazole as native photo-cross-linkers for chemoproteomics, offering direct interactome mapping methods for tetrazole/isoxazole drug development. I am also passionate about crafting small-molecule probes/inorganic nanomaterials for precise, targeted cancer theranostics.

Interests
  • Chemical biology
  • Medicinal Chemistry
  • Nanomaterials
  • Cancer theranostics
Education
  • PhD in Chemistry, 2021

    City University of Hong Kong

Professional Experience

 
 
 
 
 
University of California San Francisco
Postdoctoral Scholar
January 2024 – Present San Francisco

Projects include:

  • Development of trioxolane antimalarials and anticancer drugs
  • Small-molecule probes for targeted radioligand therapy
 
 
 
 
 
Sun Yat-sen University
Postdoctoral Researcher
October 2022 – December 2023 Shenzhen

Projects include:

  • Self-assembly nano-PROTAC for synergetic photo-chemo-therapy
  • Black phosphorus nanomaterials for biomedical application
 
 
 
 
 
City University of Hong Kong
Doctor of Philosophy
September 2018 – September 2022 Hong Kong

Projects include:

  • Isoxazole-based photo-cross-linker for photoaffinity labeling and chemoproteomics
  • Self-assembly activatable photosensitizers for cancer Nanotheranostics

Recent Publications

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(2024). Synthesis and In Vivo Profiling of Desymmetrized Antimalarial Trioxolanes with Diverse Carbamate Side Chains. In ACS Med. Chem. Lett. 2024.

PDF Cite DOI American Chemical Society

(2024). UniPTM: Multiple PTM site prediction on full-length protein sequence. In bioRxiv 2024.08.03.606471.

PDF Cite DOI bioRxiv Source Code

(2024). A tandem activity-based sensing and labeling strategy reveals antioxidant response element regulation of labile iron pools. In PNAS 2024, 121(28), e2401579121.

PDF Cite DOI PNAS PubMed

(2024). Reactivity-Tunable Fluorescent Platform for Selective and Biocompatible Modification of Cysteine or Lysine. In Adv. Sci. 2024, 11, 2402838.

PDF Cite DOI Wiley Press PubMed

(2024). A General Cyanine-Based Platform for Designing Robust Dual-Channel Near-Infrared Fluorescent and Photoacoustic Probes. In Adv. Funct. Mater. 2024, 2400597.

PDF Cite DOI Wiley Online Library

Contact

I’m delighted to collaborate with researchers worldwide to address important questions and make meaningful advancements. Feel free to contact me via email or social media.