My research focuses on using new chemical approaches to advance drug discovery and therapeutic options. I have developed tetrazole and isoxazole as native photo-cross-linkers for chemoproteomics, offering direct interactome mapping methods for tetrazole/isoxazole drug development. I am also passionate about crafting small-molecule probes/inorganic nanomaterials for precise, targeted cancer theranostics.
PhD in Chemistry, 2021
City University of Hong Kong
Projects include:
Projects include:
Projects include:
We have developed a GSH-triggered, activatable, and cancer-targeting probe, MBP, based on our rational design of a small NIRF photosensitizer, methylene blue. This multifunctional probe can self-assemble and present as nano-photosensitizer, MBNPs. Hence, an “all-in-one” cancer phototheranostic strategy with multiple cancer-targeting abilities and upgraded PDT mode has been proposed and established.
Isoxazole is an essential pharmacophore in drug discovery. In this study, we investigated the photochemistry of isoxazole with biomolecules and developed it as a natively embedded photo-cross-linker for chemoproteomics and drug discovery. With this strategy, two isoxazole-containing drugs were successfully applied to chemoproteomic platforms to uncover their cellular targets and interactions.
I’m delighted to collaborate with researchers worldwide to address important questions and make meaningful advancements. Feel free to contact me via email or social media.